Ionic Liquids for Peptide Delivery
Samir Mitragotri
Professor, Harvard University
Delivery of peptides and other biologics is limited by their poor stability and low bioavailability across biological barriers. We sought to overcome these biological barriers using ionic liquids (ILs). ILs are organic salts that exist in a liquid form at a temperature below 100 oC. Historically, ILs have been researched and developed for industrial applications. We deigned ILs using biocompatible ions to empower their therapeutic applications. I will present a review of design principles and applications of ionic liquids to overcome key biological barriers for drug delivery.
Samir Mitragotri is the Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering at Harvard University and Wyss Institute. His research is focused on therapeutic and biomaterial development. His research has led to new technologies for treating many diseases. He is an elected member of the National Academy of Engineering, National Academy of Medicine and National Academy of Inventors. He is an author on over 400 publications. He is also an elected fellow of AAAS, CRS, BMES, AIMBE, and AAPS. He received BS in Chemical Engineering from the Institute of Chemical Technology, India and PhD in Chemical Engineering from the Massachusetts Institute of Technology.