Fragment Banking: A Strategy for Rapid Convergent Synthesis of Peptides
Charles Chase
VP Technical Business Development, Asymchem
The presentation will focus on sustainable peptide production achieved through strategic investments in state-of-the-art technologies. By utilizing a fragment-based approach combined with directed enzyme evolution, biocatalysis, and continuous processing, complex peptides are manufactured with increased efficiency, enhanced quality, and reduced environmental impact, all while ensuring competitive manufacturing costs.
Charles Chase, PhD, currently holds the role as the Vice President of Technical Business Development at Asymchem. Before joining Asymchem, he served as Vice President of Pharmaceutical Development at Elicio Therapeutics and Senior Principal Scientist at Eisai Inc. With experience spanning over 20 years in Chemistry, Manufacturing, and Controls (CMC), he possesses a deep understanding of process research and development across various substances, including oligonucleotides, peptides, and complex small molecules like Halaven®. His expertise encompasses synthesis, route optimization, CMC/CDMO management, and navigating regulatory approval processes.