Controllable and Scalable Synthesis of Polymacrocyclic and Multi-Chain Peptides Using Radical-Mediated Enzymatic Methods
Karsten Eastman
CEO, Post-doctoral Scholar, Sethera, University of Utah
Cyclic and polycyclic peptides are of considerable interest as therapeutic agents because the conformational restriction resulting from macrocyclization ensures specificity and resistance to proteolytic degradation. However, the assembly of polymacrocyclic structures is often challenging because of the necessity for multi-step syntheses involving orthogonal protecting groups.