C-terminal functionalization of recombinantly expressed proteins
Jari Willems
Chemical Scientist, Endoprotease Services BV
Functionalization of peptides and proteins plays an important role in the synthesis of drugs. Recombinant production offers a scalable and green alternative to solid-phase peptide synthesis. Insertion of non-canonical amino acids and non-peptide motifs is still very complex. This contribution focuses on traceless, enzymatic means to functionalize recombinantly produced peptides and proteins.