Cyclic Cell Penetrating Peptides
Dehua Pei
Professor of Chemistry and Biochemistry, Ohio State University
Dr Pei presents his research update.
Dehua Pei is the Charles H. Kimberly Professor of Chemistry and Biochemistry at The Ohio State University. He received his PhD degree in organic chemistry from University of California, Berkeley and was a Damon Runyon-Winchell Walter Cancer Fund postdoctoral fellow at Harvard Medical School, before joining Ohio State in 1995. His research group discovered cyclic cell-penetrating peptides (CPPs), a unique class of cell-penetrating molecules that effectively deliver a wide variety of drug modalities into the cytosol of mammalian cells, and elucidated their mechanism of action. His team also developed the methodology for chemical synthesis and screening of peptide-encoded macrocycle libraries to discover ligands against protein targets. His group is currently applying these technologies to develop intracellular biologics for the treatment of previously intractable diseases, such as rare genetic diseases and those caused by faulty intracellular protein-protein interactions. He is a co-Founder and Chief Scientific Advisor of Entrada Therapeutics.