Unique chemistry for safely building biomaterials in the presence of peptide and proteins
Pete Mariner
Director of Wound Healing, Mosaic Biosciences
While the use of polymeric materials as vehicles for protein-based biologics is not a novel concept, Mosaic’s platform thiol-ene chemistry is uniquely suited for safely building polymer networks in the presence of peptides and proteins due to its low reactivity with amino acid side chains. Moreover, precise control over network structure afforded by step-growth polymerization allows for the rational design of matrices that can be built to control drug release and degradation. In wound healing applications, this system is being used to create biomaterials that are responsive to cell-mediated degradation mechanisms, support cellular migration, and are easily cleared from the body as wound healing and tissue repair/regeneration progresses.